How to Treat Hormone Imbalance in Women With HGH and TRT

Testosterone replacement therapy (TRT) and human growth hormone (HGH) injections can be instrumental to balancing hormones in women as they age.

Hormones are chemical messengers that are critical to many bodily functions and overall health. In a woman’s body, hormones control everything from sexual function and fertility to mood and metabolism. Of the hormones that impact women’s health, estrogen and progesterone are probably the ones you are most familiar with. However, women’s bodies make and need testosterone as well. In addition, human growth hormone, or HGH, is also critical to a woman’s health and wellness. Any of these hormones can become imbalanced as women approach and enter menopause. Such “age-related” hormone imbalances in women are treated with hormone replacement therapy or HRT.

Hormones are chemicals produced by glands in the endocrine system and released into the bloodstream. A hormone imbalance occurs when there is too much or too little of a hormone. While there are certain medical conditions that occur from too much of a given hormone, too little hormones is the far more common problem. This is particularly true as women age; for the most part, we will be discussing hormone imbalance in women that occurs due to age-related hormone decline.

About Hormone Imbalances

Every woman knows what it is like to be “hormonal.” While that is sometimes used as an unflattering term, the fact of the matter is that hormonal imbalances in women can be to blame for a wide range of unwanted symptoms, from weight gain, low energy, and sexual health issues to mood swings.

Symptoms of Hormone Imbalance

Since a woman’s hormones are involved in the regulation of so many different bodily functions, the symptoms of hormone imbalance can be quite varied and often involve the imbalance of more than one hormone.

Hormonal imbalance symptoms in women include:

Symptoms of hormone imbalance

  • Night sweats and hot flushes
  • Reduced interest in sexual activity
  • Infertility
  • Mood swings
  • Trouble sleeping
  • Depression
  • Changes in appetite
  • Deepened voice
  • Altered heart rate
  • Soreness in the breasts
  • Swollen face
  • Headaches
  • Difficulty concentrating
  • Bloating (body)
  • Weight gain
  • Weight loss
  • More or less frequent urination or bowel movements
  • Dry skin
  • Skin rashes
  • Bulge in the neck
  • Weak bones
  • Thin hair
  • Hair loss
  • Changes in blood sugar
  • Changes in sensitivity to heat or cold
  • Thirst
  • Vision problems
  • Enlarged clitoris
  • Infertility
  • Long-lasting fatigue

Causes of Hormone Imbalance in Women

Throughout her life, a woman’s hormone levels will naturally fluctuate. Events like menstruation, pregnancy, and menopause are typical milestones where hormonal shifts are expected. However, beyond these normal changes, there are numerous medical and environmental factors that can also disrupt hormonal balance.

Hormones play a pivotal role in nearly every aspect of female health, and they’re regulated by a complex network of glands throughout the endocrine system. Because of this, there are many potential contributors to hormone imbalance.

Some of the most common causes include:

  • Poor dietary habits
  • Chronic stress
  • Excess body fat
  • Pituitary gland abnormalities
  • Type 1 and Type 2 diabetes
  • Genetic conditions such as Prader-Willi syndrome
  • Inherited forms of pancreatitis
  • Trauma to the endocrine system
  • Severe infections or immune responses
  • Long-term exposure to environmental toxins, including pesticides and herbicides
  • Allergic responses
  • History of anabolic steroid use
  • Turner syndrome, a chromosomal disorder affecting the development of reproductive organs
  • Thyroid dysfunction (hyperthyroidism or hypothyroidism)
  • High intake of phytoestrogens (naturally occurring estrogens in foods like soy)
  • Elevated glucagon levels
  • Insulin dysregulation/insulin resistance
  • Parathyroid hormone irregularities
  • Use of hormonal contraceptives
  • Hormone replacement medications
  • Noncancerous growths affecting hormone production
  • Cancers of the endocrine system
  • Cancer treatments, including radiation and chemotherapy
  • Thyroid nodules, which may be benign or, less commonly, cancerous
  • Excess production of cortisol
  • Addison’s disease (marked by cortisol and aldosterone deficiency)
  • Low iodine intake
  • Eating disorders such as anorexia
  • Prescription medications that impact hormonal function

Although this list may seem extensive, the most prevalent and impactful cause of hormonal imbalance in women—particularly as they approach middle age—is age-related hormone decline. Testosterone and human growth hormone (HGH) both tend to drop significantly as women transition through menopause, leading to symptoms like fatigue, mood changes, weight gain, loss of muscle tone, and diminished libido.

Fortunately, these age-related hormonal imbalances can be addressed safely and effectively through comprehensive HRT programs. At Nexel Medical, we specialize in tailoring testosterone and HGH therapy for women, customizing treatment plans to support your long-term health, symptom relief, and overall wellness goals.

Medical Conditions That Can Cause Hormone Imbalances

Medical conditions that can cause hormone imbalances in women include ovarian cancer, polycystic ovary syndrome (PCOS), early menopause, and/or primary ovarian insufficiency (POI).

While these various medical conditions and other glandular malfunctions can all cause hormone imbalance in women, the most common reason that women will be experiencing hormonal issues is the age-related hormone decline that occurs as women approach and enter menopause.

How Do Doctors Treat Hormone Imbalances?

Most hormone imbalances in women are treated with a prescription for hormone replacement therapy. Our doctors believe that the safest and most effective form of hormone replacement therapy is bioidentical hormone replacement therapy, also known as BHRT.

The synthetic hormones that are made by the big pharmaceutical companies are not the same as the hormones produced by your body. In fact, they are specifically designed to be unique so that drug companies can patent them for bigger profits.

Since bioidentical hormones are exact replicas of your own hormones, they are better recognized and better absorbed by your body. Bioidentical hormones are the safest and most effective type of hormone replacement therapy available.

Bioidentical hormones are given in several ways. In addition to injections, creams, patches, pills, gels, and pellets are among the ways BHRT can be prescribed. Your doctor will determine which delivery method is best for you based on your particular needs and lifestyle.

As compared to their synthetic counterparts, bioidentical hormones have been found:

  • To be more effective
  • To be safer and better tolerated
  • To produce greater health benefits and positive effects
  • To reduce the risk of cancer or heart disease

As opposed to the hormones created from plant sources, synthetic hormones are made from animal sources that your body sees as “hostile invaders.” Your body does not recognize them and may treat them as toxins, which at best lowers their effectiveness, and at worst, may trigger severe side effects such as heart attacks, stroke, or cancer.

Testosterone Replacement Therapy for Women

Even though testosterone is a “male hormone,” women produce and need testosterone too. And, like men, women’s testosterone levels also decline as they age.

When we consider hormone replacement therapy (HRT) in women, we are usually thinking of replacing estrogen, or progesterone therapy to deal with menopausal symptoms. However, much of the latest research indicates that women, too, can benefit from testosterone replacement, particularly those women who are already receiving HRT to combat the typical symptoms of menopause. In fact, current research seems to indicate that it is the drop in testosterone, and not estrogen, that is responsible for many of the hormonal issues that women experience just before, during, and after menopause.

What Are the Benefits of Testosterone Therapy for Women?

Testosterone therapy for women is a medically recognized and effective approach to enhancing quality of life for women experiencing symptoms tied to low testosterone levels.

In most cases, TRT for women is not prescribed as a standalone treatment for women. Instead, it is typically included as part of a broader hormone replacement therapy (HRT) regimen. Many women experience significant improvements when testosterone is combined with estrogen, often through skin patches or subdermal pellets that provide a steady, low-dose release. This combination has been associated with fewer hot flashes, improved mood stability, and meaningful relief from menopause-related sexual health concerns such as reduced libido, vaginal dryness, or discomfort during intimacy.

Testosterone therapy for women can be administered in a variety of ways, depending on the individual’s needs and treatment goals. These options include subcutaneous pellets, injections, topical creams, skin patches, oral lozenges, or a combination of these delivery methods. Your doctor at Nexel Medical will help determine the most appropriate protocol for your specific condition and lifestyle.

One of the safest and most effective types of testosterone therapy for women involves the use of bioidentical hormones. These compounds are chemically and structurally identical to the hormones naturally produced by the body. Because bioidentical hormones are sourced from natural plant-based materials and closely mimic human hormones at the molecular level, they are generally considered safer and better tolerated than synthetic hormone formulations. Patients who undergo HRT with bioidentical testosterone tend to report fewer adverse effects.

Additional benefits of testosterone replacement therapy for women may include:

  • Better cardiovascular health
  • Increased bone density reduces the risk of osteoporosis
  • A reduction in fat mass
  • Greater muscle strength and increased muscle mass
  • Enhanced emotional well-being
  • Improved quality of sleep

HGH Therapy for Women

For the most part, growth hormone in women plays the same role in women as it does in men. Growth hormone’s main function is to stimulate the growth and maturity of bone and muscle tissue. As such, it is primarily responsible for a child growing up to be an adult of full height and stature. Even as adults, we continue to need HGH. HGH helps to regulate and maintain the health of all of your tissues and organs. It plays a vital role in keeping your immune system strong and healthy. It keeps your skin tight and fit and has been linked to sexual performance, emotional wellness, and mental acuity.

HGH also plays some specific roles in women when it comes to sexual health. The vaginal dryness, lack of libido, and painful intercourse that many women suffer during their perimenopause and menopausal years can all be helped by HGH replacement therapy. Also, as in men, HGH seems to have a positive effect on fertility in women. HGH therapy has been found to improve or induce ovulation in women who have had fertility issues. Studies have found that HGH, along with IGF-1 and IGF-2, works to stimulate the maturation of ovarian follicles into viable eggs.

Growth Hormone Therapy Benefits for Women

Other than the specific benefits of HGH therapy for women on fertility and sexual health, the balance of the benefits of HGH therapy for women is the same as they are for men. Well-reviewed studies have found that the benefits of growth hormone therapy for women, as well as men, include:

HGH benefits for women

  • Increased exercise capacity
  • Improved sleep
  • Improved sex drive and enhanced sexual performance
  • Improved heart health, reduction of “bad” cholesterol
  • Improved body weight, increased lean body mass
  • Increased muscle mass
  • Increased energy
  • Renewal and revitalization of all tissues and organs
  • Younger-looking skin
  • Reduction of systemic inflammation, leading to an overall improvement in wellness and vitality
  • Improved healing and immune response
  • Improved memory, focus, and other cognitive abilities
  • Improved mood and an overall better sense of wellness

Many well-respected studies have concluded that adding HGH to a program of HRT can significantly improve the quality of life of menopausal and postmenopausal women.

What Are the Benefits of Hormone Replacement for Hormone Imbalance?

In addition to the relief of sexual health issues and the other symptoms of hormone imbalances, hormone replacement for women also has been shown to:

  • Strengthen bones and increase bone density
  • Improved cognitive function
  • Increased energy levels and improved vitality
  • Improvements in overall body composition and reduction of fat
  • Decrease wrinkles, improve the texture and elasticity of the skin
  • Provide improved energy and daily stamina
  • Improve the health and vitality of hair and nails
  • Reduce the occurrence of mood swings, depression, and anxiety

Recently published studies have concluded that properly administered and supervised bioidentical hormone therapy significantly improves the quality of life of menopausal, postmenopausal, or any woman suffering from hormone imbalance due to low hormone levels.

Thanks to our personalized approach to HRT for women, at Nexel Medical most of our female patients go through their entire course of therapy with few if any side effects. This attention to detail and patient safety is just one of the many factors that sets as apart from other clinics who provide HRT for women.

Are There Any Alternative or Natural Ways to Treat Hormone Imbalances?

Medical professionals generally regard HRT as the best ways to treat hormone imbalances in women. However, there are some natural or alternative methods that have been shown to be somewhat effective in minimizing hormonal deficiencies in women.

Some herbs and natural supplements that have been suggested to help treat hormone imbalance in women include:

  • Nigella seeds
  • Ashwagandha
  • Black cohosh root
  • Chasteberry
  • Marjoram

In addition, try these lifestyle changes to help keep hormones in balance:

  • Eat Enough Protein at Every Meal. Consuming an adequate amount of protein is extremely important.
  • Engage in Regular Exercise.
  • Avoid Sugar and Refined Carbs
  • Learn to Manage Stress
  • Consume Healthy Fats
  • Avoid Overeating and Undereating
  • Drink Green Tea
  • Eat Fatty Fish Often

What Does the Medical Research Say About Treating Hormone Imbalance in Women?

Most of the medical research agrees that when properly prescribed and monitored by your physician, hormone replacement therapy, and in particular bioidentical hormone replacement therapy, is the best way to return hormonal balance.

The latest research on using hormonal therapy for treating women with hormone deficiencies has also found that HRT is much safer than it was once thought to be. This specifically relates to the risks of heart disease and breast cancer.

A very recent study published in 2021 found that – in line with other evidence – the risks of hormone therapy are generally low and that breast cancer risks were extremely low with bioidentical HRT.

Hormone imbalances in women can lead to weakened bones and an increased risk of osteoporosis. A 2014 study published in Menopause Review, looking at ways to minimize osteoporosis-related fractures in postmenopausal women, concluded, “Hormone replacement therapy (HRT) at different doses rapidly normalizes turnover, preserves bone mineral density (BMD) at all skeletal sites, leading to a significant reduction in vertebral and non-vertebral fractures.”

A 2007 study looking into the effectiveness of danazol, a hormonal treatment used to treat hormone imbalances in women with recurrent deeply infiltrating endometriosis, concluded that “Vaginal danazol resulted ineffective medical treatment for the various painful symptoms in women with recurrent deeply infiltrating endometriosis, and because of the lack of significant adverse effects, it may be proposed as an alternative to repeated surgery.”

Frequently Asked Questions About Hormone Imbalances in Women

What Is a Hormone Imbalance?

A hormone imbalance is defined as having too little or too much of a given hormone in the bloodstream.

How Are Hormone Imbalances Treated?

Treatment for hormonal imbalances is determined by the specific cause and highly tailored to each individual woman. Each female may require a different regimen of treatment. Medical treatments and lifestyle changes show the best long-term results. The most common treatment for hormone imbalances due to hormone deficiencies is hormone replacement therapy.

Do Hormone Imbalances Only Affect Menopausal Women?

Even women who have not yet entered menopause can suffer from hormone imbalances. In particular, women over 35 who have not yet entered menopause can suffer from low testosterone. Low testosterone in women can affect mood, sexual wellness, and a recent study indicates that it can also increase a woman’s risk of cardiovascular disease.

What Are Bioidentical Hormones?

Hormone imbalances in women

Bioidentical hormones are natural compounds derived from plants. Unlike commonly prescribed synthetic hormones, bioidentical hormones have the same molecular structure as hormones produced by the body, allowing them to be metabolized much more easily. That chemical compatibility with the body yields more effective symptom relief than synthetic hormones with fewer risks and side effects.

What Are the Five Most Common Hormone Imbalances in Women?

Women have several critical hormones that regulate various important bodily processes. The five most common hormones in women that can become imbalanced are:

  • Estrogen
  • Progesterone
  • Human growth hormone
  • Testosterone

In addition to these five, women may also suffer imbalances of thyroid hormone and adrenal hormones.

Now that you know a lot more about how to treat hormone imbalance in women with TRT and HGH, why not contact us and learn more about the many life-changing benefits of hormone replacement therapy for females?

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