Get Started
Complete the short form belowto Contact a Nexel Medical physician
When most men begin testosterone replacement therapy (TRT) to address the effects of low testosterone—such as fatigue, weight gain, low libido, and muscle loss—they expect to feel stronger, younger, and more energized. And in many cases, they do. But what often gets overlooked is the body’s natural conversion of testosterone into estrogen—a process that can create new challenges if not properly managed.
As men age, their hormonal landscape becomes more complex. Not only does testosterone decline steadily after the age of 30, but the enzyme aromatase, which converts testosterone into estrogen, becomes more active, particularly in men with higher body fat. This means that older men receiving TRT may experience increased estrogen levels as their bodies convert the added testosterone into estrogen at a higher rate.
While estrogen is essential for male health—supporting bone density, sexual function, and mood—it must remain in balance with testosterone. Too much or too little estrogen can interfere with the very benefits TRT is meant to provide. That’s why estrogen management is a critical and often underappreciated part of successful testosterone therapy.
At Nexel Medical, we specialize in helping men navigate this delicate balance. Our expertise in hormone optimization includes careful monitoring of both testosterone and estrogen levels, ensuring that your testosterone injections deliver the benefits you expect, without the complications of hormonal imbalance.
Estrogen is often misunderstood in the context of male health, yet it is vital. Men produce estrogen primarily through the conversion of testosterone via the enzyme aromatase. This natural process takes place in fat tissue, the adrenal glands, the brain, and the testes.
Estrogen is responsible for much more than most people realize—it helps maintain bone density, supports muscle recovery, contributes to a healthy heart, regulates mood, and even plays a role in sexual performance. Without the right amount of estrogen, many benefits typically attributed to testosterone may fall short. A healthy testosterone-to-estrogen ratio is key to a man’s overall wellness.
In men, the most biologically active form of estrogen is estradiol (E2). While individual needs vary, a healthy range for estradiol is typically 10 to 40 pg/mL. These numbers, however, are only part of the picture.
At Nexel Medical, we don’t rely on generic “normal” ranges. Instead, we assess whether your levels are optimal for you. Our hormone specialists look at your age, body composition, and symptoms to determine what your personalized hormone profile should look like—then work to achieve it.
Hormones operate as an interconnected network. That’s why estrogen balance in men is just as important as testosterone levels. Too much or too little estrogen—even when testosterone appears to be in range—can cause health issues.
At Nexel Medical, we carefully monitor your entire hormonal landscape. We take into account testosterone, estrogen, DHEA, cortisol, and other factors to create a finely tuned hormone therapy plan designed for long-term success.
Causes:
Elevated estrogen levels in men are often linked to an increase in aromatase activity, the enzyme that converts testosterone into estrogen. This is more common in men who carry excess body fat, experience chronic stress, or have impaired liver function. It may also occur during testosterone therapy if the aromatization process isn’t properly regulated.
Signs of high estrogen:
Treatment:
High estrogen levels can be addressed through aromatase inhibitors (AIs), which limit estrogen production. Additionally, lifestyle interventions like weight loss, dietary changes, and adjusting TRT dosages can significantly improve hormone balance.
Causes:
Low estrogen may result from extreme cases of low testosterone or overuse of estrogen-suppressing medications. In both cases, the body fails to produce enough estrogen to support its essential functions.
Symptoms:
Treatment:
In many cases, correcting testosterone deficiency also restores estrogen to healthy levels. When necessary, Nexel Medical may use estrogen therapy to support bone health and resolve symptoms, always using lab data to avoid overtreatment or suppression.
In men, estrogen therapy typically refers to regulating estrogen, not adding more of it. Our focus is on keeping estrogen in a healthy range, particularly when patients are on testosterone replacement therapy.
Medications may include:
Our goal at Nexel Medical is precision. We don’t just treat hormone numbers—we restore balance so your body can perform at its peak without unwanted side effects.
As men age, testosterone production naturally declines. But that’s only half the story. As testosterone levels drop, the ratio between testosterone and estrogen can become imbalanced due to increased aromatization. This process causes more of the remaining testosterone to convert into estrogen.
This hormone shift is especially pronounced in men receiving testosterone injections. A sudden increase in testosterone can trigger more conversion to estrogen than the body needs. Estrogen is essential, but in the wrong proportions, it may interfere with libido, energy, and reproductive health.
Over the course of your TRT, we use hormone blood tests to monitor and adjust therapy to prevent these fluctuations and maintain a healthy hormonal ratio.
Testosterone and estrogen work in tandem. When testosterone drops—as it typically does in men over 40—so does estrogen, sometimes leading to symptoms that mimic low testosterone alone. In some cases, aromatization compensates by converting more testosterone into estrogen, further disrupting the hormone balance.
Symptoms of this imbalance include:
This is why hormone therapy must be carefully managed. Our team at Nexel Medical doesn’t just restore testosterone levels—we ensure your entire endocrine system is functioning in harmony.
Every man converts some testosterone into estrogen. This is normal and necessary. However, when men receive testosterone therapy—especially via injections—this conversion can accelerate.
Increased estrogen levels may counteract the benefits of TRT if not properly controlled. For this reason, some men may benefit from estrogen blockers as part of their testosterone treatment.
At Nexel Medical, your TRT program is personalized. We monitor your lab results regularly and adjust your therapy as needed to preserve the balance between testosterone and estrogen, keeping you healthy, energetic, and symptom-free.
Beyond hormone therapy, lifestyle plays a big role in managing estrogen levels. We educate and support patients on natural ways to support hormonal health, such as:
These integrative strategies are part of every treatment plan at Nexel Medical.
At Nexel Medical, we go beyond testosterone and estrogen. Our comprehensive hormone optimization programs are designed to support the entire hormonal network. In addition to being recognized experts in TRT for strength, energy, and sexual health, we offer a variety of growth hormone therapies to help you be your best at any age.
Whether you need the benefits of TRT, HGH Therapy, or both, what sets Nexel Medical apart is our commitment to precision medicine. Each patient’s plan is based on advanced diagnostics, expert interpretation, and continuous monitoring to achieve optimal results.
Whether you’re struggling with low testosterone, elevated estrogen, or any form of hormonal imbalance, Nexel Medical is your trusted partner. Our experienced team provides personalized care, advanced hormone therapies, and science-backed strategies to help you reclaim your health and vitality.
Contact us today and take your first step toward lasting hormone balance and a better quality of life.
Complete The Short Form Below To Contact a Nexel Medical Physician
